TODAYS PICK (20-07-2010)

Question history: PGI ??

Diabetes milletus is best monitored by
a)Post prandial glucose levels
b)Fasting glucose levels
c)glycated Hemoglobin
d)urine sugar

ans:c

Discussion: reference Harrisons 17th ed,2296 page
Glycated Hemoglobin(HbA1c)
  • Measurement of glycated hemoglobin is the standerd method of assessing the longterm gllycemic control of Diabetes milletus.
  • HbA1c is non-enzymatically formed when there is consistent elevation of plasma glucose levels.
  • This HbA1c levels reflect the glycemic history of last 2-3 months since the lifespan of RBC is about 120 days.
  • HbA1c levels becomes unreliable in conditions of: 
  1. Hemoglobinopathies 
  2. Hemolytic anemia    
  3. Uremia                     

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