TODAYS PICK (19-07-2010)

Question history: AIPG 08

Which of the following is true regarding prions?
a)It is a DNA particle
b)immunogenic
c)Infectious
d)Not sensitive to proteins

Ans:c

Discussion: reference Ananthnarayan textbook of Microbiology

PRIONS:
  1. Prions are proteinacious infectious particles without any dectectable nuclear material in them. they are resistant to heat, uv-rays and nucleases,and sensitive to proteases. 
  2. They have the ability to convert the normal non-infectious form of protein into infectious form of prion.
  3. Prions are responsible for several fatal neurodegenerative disorders known as transmissable spongiform encephalopathies or Prion diseases. In these conditions secondary or tertiary protein is altered.
  4. Prions are causative organism for
  •  Kuru and crutzfeldt-jacobs disease in man
  • Mad cow disease in animals                      
    •  

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